THIENOi2,3-döPYRIMIDINEDIONES AS INHIBITORS OF T-CELL PROLIFERATION

摘要

The invention relates to a compound of formula (1) in which Q is -CO- or -C(RSUP4/SUP)(RSUP5/SUP)-, where RSUP4 /SUPis a hydrogen atom or CSUB1-4/SUBalkyl and RSUP5 /SUPis a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system where up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.