RELEASE PROMOTING FUNCTION OF NEUROTRANSMITTER BY SPHINGOSINE 1 PHOSPHORIC ACID AND ITS APPLICATION

摘要

PROBLEM TO BE SOLVED: To identify the action of sphingosine 1 phosphoric acid (S1P) specific to nervous system and apply the result to the treatment of diseases of the nervous system and the like.;SOLUTION: The invention is based on a neurospecific new action of the S1P identified this time such that the S1P promotes the release of a neurotransmitter from the neurocytes, and provides a method of regulating the release of the neurotransmitter from the neurocytes by administering an agonist or an antagonist of the S1P or its accepter to the neurocytes, or by controlling the production of the S1P in the neurocytes, also provides a release control agent of the neurotransmitter, a nervous disease treating medicine and a screening method of the release control agent of the neurotransmitter and the nervous disease treating medicine like this.;COPYRIGHT: (C)2008,JPO&INPIT