RECOMBINANT VIRUS VECTOR DERIVED FROM HHV-6 OR HHV-7, AND UTILIZATION THEREOF

摘要

PPROBLEM TO BE SOLVED: To provide a recombinant HHV-6 and HHV-7, safely and precisely regulating unexpected in-vivo proliferation of the virus. PSOLUTION: The recombinant virus vector derived from HHV-6 has a part of U2, U3, U4, U5, U6, U7, U8, U24 and U25 genes in HHV-6 genome, recombined with a polynucleotide encoding a thymidine kinase possessed by a virus belonging to the herpesvirus family and an exogenous polynucleotide. The recombinant virus vector derived from HHV-7 has a part of U2, U3, U4, U7, U8, U24, U24a and U25 genes in HHV-7 genome, recombined with the polynucleotide encoding the thymidine kinase possessed by the virus belonging to the herpesvirus family and the exogenous polynucleotide. PCOPYRIGHT: (C)2008,JPO&INPIT