METHOD FOR PRODUCING 3-O-ALKYL-5,6-O-(1-METHYLETHYLIDENE)-L-ASCORBIC ACID AND METHOD FOR PRODUCING 5,6-O-(1-METHYLETHYLIDENE)-L-ASCORBIC ACID

摘要

PROBLEM TO BE SOLVED: To provide an industrially advantageous method for the production of 3-O-alkyl-5,6-O-(1-methylethylidene)-L-ascorbic acid.;SOLUTION: The method for producing 3-O-alkyl-5,6-O-(1-methylethylidene)-L-ascorbic acid comprises a first step to react L-ascorbic acid with acetone in the presence of an acid catalyst to form 5,6-O-(1-methylethylidene)-L-ascorbic acid and a second step to react the 5,6-O-(1-methylethylidene)-L-ascorbic acid produced by the first step with an alkylation agent in the presence of a base to form 3-O-alkyl-5,6-O-(1-methylethylidene)-L-ascorbic acid, wherein the first step is carried out in the presence of 2,2-dimethoxypropane.;COPYRIGHT: (C)2009,JPO&INPIT