FUSION PROTEIN OF SWINE BREEDING/RESPIRATORY DISORDER SYNDROME VIRUS AS PRRS VACCINE

摘要

PPROBLEM TO BE SOLVED: To provide a fusion protein as a PRRSV subunit vaccine inducing PRRSV neutralization value in swine. PSOLUTION: The PRRSV subunit vaccine is provided, comprising PE-PQGAB-K3 as the fusion protein that induces the neutralization value in swine and comprises a chimeric polypeptide containing the N-terminal part of PRRSV ORF5 and ORF6 structural protein, part of a Pseudomonas aeruginosa exotoxin A-bound and rearranged domain, and a carbonyl-terminated domain comprising a sequence KDEL-KDEL-KDEL(K3). Reduction of inflammation owing to a group of PE-PQGAB-K3 vaccines in the lung of a swine infected with PRRSV indicates that there is no antigen-specific allergic effect in PQGAB. Importantly, in a swine infection test, the PE-PQGAB-K3 vaccine is better in defence against PRRSV infection than a control group. PCOPYRIGHT: (C)2008,JPO&INPIT