首页> 外国专利> from l- ephedrine, respectively, R d- or ephedrine - manufacturing method (methamphetamine) N, α- dimethyl phenethylamine - (+) - (-) - S N, α- dimethyl phenethylamine or (Reb methamphetamine)

from l- ephedrine, respectively, R d- or ephedrine - manufacturing method (methamphetamine) N, α- dimethyl phenethylamine - (+) - (-) - S N, α- dimethyl phenethylamine or (Reb methamphetamine)

机译:分别从左旋麻黄碱,右旋麻黄碱或麻黄碱-制造方法(甲氨苯丙胺)N,α-二甲基苯乙胺-(+)-(-)-S N,α-二甲基苯乙胺或(Reb甲基苯丙胺)

摘要

Of formula III d- or ephedrine of formula IV from l- ephedrine, R - (-) - N, α- dimethyl phenethylamine S (Reb methamphetamine, Formula I) or - (+) - N, α- dimethyl phenethyl amine (methamphetamine , A process for the preparation of formula II), the reaction mixture containing the formula VI or formula V the N- acylated ephedrine was acylated with an acylating agent of formula IV or d- the l- ephedrine base (a) or Formula III The acid hydrolysis comprising the steps of producing, the method of preparing the compound of formula VIII or formula VII with deoxygenated N- acylated ephedrine and (b) using the Raney nickel catalyst, deoxygenation product of (c) above the method comprising the steps of: obtaining a methamphetamine or methamphetamine Lev by decomposition.
机译:式III的去氧麻黄碱的式III d-或麻黄碱,R-(-)-N,α-二甲基苯乙胺S(Reb甲基苯丙胺,式I)或-(+)-N,α-二甲基苯乙胺(甲基苯丙胺) ,制备式II)的方法,将含有式VI或式V的反应混合物中的N-酰化麻黄碱用式IV或d-1-麻黄碱碱(a)或式III酰化。酸水解包括制备步骤,用脱氧的N-酰化麻黄碱制备式VIII或式VII的化合物的方法和(b)使用阮内镍催化剂,上述方法(c)的脱氧产物,该方法包括以下步骤:通过分解获得甲基苯丙胺或甲基苯丙胺。

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