Identification of phospholipase A2 as a target in cancer treatment with particular emphasis on colorectal cancer and its mechanism of action

摘要

A peptide of phospholipase A2 had been detected in human plasma and synthesised. The peptide was injected into mice and gene expression profiling on many organs performed. Phospholipase A2 showed significant effects on regulation of gene expression in the liver. The genes affected are members of the integrin signalling pathway, wnt pathway and PTEN pathway. The changes in gene expression indicate a positive effect of phospholipase A2 on cell proliferation and invasiveness. The gene annotation points at colorectal cancer.