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Polymorphic statin therapy in human OATP-C associated with effects on statin pharmacokinetics in humans
Polymorphic statin therapy in human OATP-C associated with effects on statin pharmacokinetics in humans
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机译:他汀类药物在人OATP-C中的多态性与对他汀类药物药代动力学的影响有关
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摘要
This invention relates to use of polymorphisms in human OATP-C in statin therapy because they are associated with an effect on statin pharmacokinetics (PK) in humans, especially rosuvastatin pharmacokinetics. The invention also relates to the use of OATP-C polymorphisms in predicting the efficacy and safety of statins, whose uptake in to the liver is mediated by OATP-C, especially rosuvastatin.
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