Disubstituted pyrazolobenzodiazepines useful as inhibitors of CDK2 and angiogenesis and in the treatment of breast cancer, colon cancer and prostate cancer

摘要

The present invention provides compounds of formula I wherein R1, R2, R3, R4, and R5are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.