METHOD FOR THE TREATMENT OF CORTICOSTEROID INDUCED OSTEOPENIA

摘要

PPROBLEM TO BE SOLVED: To provide synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp and their pharmaceutically acceptable salts, useful for preventing and treating corticosteroid induced osteopenia in mammals. PSOLUTION: Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic -helix, the residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence:Haa(Laa Laa Haa Haa)SB2/SBLaa, and their pharmaceutically acceptable salts are useful for the prophylaxis, and treatment of corticosteroid induced osteopenia in mammals. PCOPYRIGHT: (C)2008,JPO&INPIT