Duffy antigen chemokine receptor and use thereof

摘要

The invention relates to Duffy antigen receptor for chemokines and uses thereof. In one embodiment, the invention provides a method for screening for drug candidates that inhibit angiogenesis. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds to the Duffy antigen receptor for chemokines. In another embodiment, the invention provides a method for inhibiting tumor growth. In yet another embodiment, the invention provides a method for inhibiting angiogenesis. In a further embodiment, the invention provides a method for promoting tumor necrosis.