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Biologically active peptides derived from functional domains of proteins with improved bactericidal / permeability and uses thereof
Biologically active peptides derived from functional domains of proteins with improved bactericidal / permeability and uses thereof
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机译:源自具有改善的杀菌/通透性的蛋白质功能域的生物活性肽及其用途
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摘要
The present invention provides peptides having an amino acid sequnce that is the amino acid sequence of a human bactericidal/permeability-increasing protein (BPI) functional domain or a subsquence thereof, and variants of the sequence or subsequence thereof, having at least one of the BPI biological activities, such as heparin binding, heparin neutralization, LPS binding, LPS neutralization or bactericidal activity. The invention provides peptides and pharmaceutical compositions of such peptides for a variety of therapeutic uses.
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