首页>
外国专利>
Synthesis of Minus Beta Element, Minus Beta Elemental, Minus Beta Elementenol, Minus Beta Fluorinated Elementene and Their Analogues, Intermediates and Drugs
Synthesis of Minus Beta Element, Minus Beta Elemental, Minus Beta Elementenol, Minus Beta Fluorinated Elementene and Their Analogues, Intermediates and Drugs
展开▼
机译:负β元素,负β元素,负β元素烯醇,负β氟代元素烯及其类似物,中间体和药物的合成
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention provides convergent processes for preparing (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, and (-)-beta-elemene fluoride and analogues thereof. Also provided are intermediates useful for preparing (-)-beta-elemene. The present invention further provides novel compositions based on analogues of (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride and methods for the treatment of cancer, such as brain tumor, lung cancer, breast cancer, prostate cancer, ovarian cancer, colorectal cancer, gastric intestional cancer, and stomach cancer. The inventors propose a combination therapy using 1) one or more of the following anti-cancer agents: including, but not limited to, Cisplatin, 5-FU, Taxol, Taxol derivatives, and any anti-cancer agent, and 2) one or more of the following (-)-beta-elemene and its analogs, including (-)-beta-elemene, (-)-beta-elemenal, (-)-beta-elemenol, (-)-beta-elemene fluoride, and their analogs, and (-)-beta-elemene's intermediate in its chemical synthesis, for the treatment of cancer, especially for the treatment of brain tumor, lung cancer, ovarian cancer, bladder cancer, cervical cancer, colon cancer, breast cancer, and prostate cancer.
展开▼