It reacted uniquely production method of the anti- human fibrin monomer unique monoclonal antibody and the said monoclonal antibody, the hybridoma and

摘要

The use of the active fibrin, a native fibrin monomer occurring at an early stage of blood coagulation, a monoclonal antibody capable of detecting soluble fibrin, hybridoma, and its monoclonal antibody To provide a sensitive and rapid measurement method for early stage of blood coagulation formation. A fibrin monomer similar to the blood fibrin monomer is used as an immunogen, and is not reactive to fibrinogen by a cell fusion method, and is contained in a native fibrin monomer Monoclonal antibodies that can be recognized simultaneously and soluble fibrin were identified. The fibrin monomer analogous compound is preferably fibrin gen, which is treated with a baton monomer similar compound, which is treated with a batroxobine ("poison").