Cell culture, a solid support for use in culturing hepatocytes in particular, their use in biological reactors and bioartificial liver system, comprising the solid support

摘要

(57) [Abstract] The present invention, the solid support for use in cell culture in vitro which comprises a hollow fiber and 3D matrix material that is permeable to gaseous carbon dioxide and gaseous oxygen and / or at least living cells using a biological reactor to maintain and / or culture the body, the living cells comprising a solid support, a chromatography was the organism district specific interest ACK and / or said solid support and a method for maintaining and / or culture. The solid support, and methods of the biological reactor is particularly suitable for culturing for use as bioartificial livers or use in bio-artificial liver, the liver cells of human or animal origin. The invention further relates to a method of bio-artificial liver such, the treatment of liver disease as well as by using the bio-artificial liver.