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Use of bispecific antibodies for pre-targeting diagnosis and pretargeting therapy
Use of bispecific antibodies for pre-targeting diagnosis and pretargeting therapy
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机译:双特异性抗体在靶向治疗和靶向治疗中的应用
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摘要
The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable conjugate. The targetable conjugate comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable conjugate further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
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