Optically active 1- (fluoro, trifluoromethyl or trifluoromethoxy-substituted phenyl) alkylamine N- monoalkyl derivative and a method of manufacturing the same

摘要

PROBLEM TO BE SOLVED: To provide a new optically active 1-(fluoro, trifluoromethyl or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative used as an important intermediate for medicines and agrochemicals, and to provide a method for producing the same.;SOLUTION: This method for producing the optically active 1-(fluoro, trifluoromethyl or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by formula [4] [R is F, trifluoromethyl or trifluoromethoxy; (n) is an integer of 1 to 5; R₁ and R₂ are each a 1 to 6C alkyl; * shows an asymmetric carbon] comprises reacting an optically active secondary amine represented by formula [1] (Me is methyl; Ar is phenyl or naphthyl) with an alkylating agent represented by formula [2] (X is a releasable group) in the presence of a base and then hydrolyzing the obtained optically active tertiary amine represented by formula [3].;COPYRIGHT: (C)2004,JPO