7α- (5-Methylaminopentyl) -estraditriene, process for its production, pharmaceutical preparations containing this 7α- (5-methylaminopentyl) -estraditriene, and their use for producing a medicament

摘要

This invention describes the new 7alpha-(5-methylaminopentyl)-estratrienes of general formula Iin whichR2 stands for a hydrogen or fluorine atom,R17 stands for a hydrogen atom, a methyl or ethinyl group,n stands for 2, 3 or 4, andx stands for 0, 1 or 2.The new compounds are strong, pure antiestrogens and can be used for the production of pharmaceutical agents for treatment of estrogen-dependent diseases, for example, breast cancer, endometrial carcinoma, prostatic hyperplasia, anovulatory infertility and melanoma.