Drugs for diseases associated with increase or decrease in total bile acid pool amount or lipid metabolic diseases, and screening methods for these drugs

摘要

As a result of creating Gpbar1-deficient mice and examining whether Gpbar1 is involved in the regulation of bile acid homeostasis and lipid metabolism, Gpbar1-deficient mice have a total bile acid pool level without change in fecal bile acid excretion levels. Diminished. In addition, the weight of Gpbar1-deficient female mice bred with high-fat diet significantly increased compared to wild-type mice, which was due to increased fat. This suggests that Gpbar1 contributes to the control of bile acid homeostasis and lipid metabolism.