detection method of abnormal function of p53, evaluation method of a compound effective in the treatment of cancer and molecular diagnostic method for cancer

摘要

The Okeru the test cell, the step of measuring the expression level of equivalent genes in function to the gene or at least one gene is selected from the group consisting of GEF-H1 and, TNFRSF9, LOC56901 CARS, MOCOS test tissue or and, a step of comparing the expression level of the corresponding gene in a normal cell or normal tissue expression level of the gene, the result of the comparison, the expression level of a gene in a test tissue or a test cell genes in normal cells or normal tissues by a method comprising the steps of determining whether or not significantly more than the amount of expression, to perform the molecular diagnosis of cancer and detection of abnormal function of p53. Molecular diagnostic methods of the present invention, and also, regardless of the presence or absence of a mutation in p53, and can detect the dysfunction of p53 without directly detecting the mutation of p53, making a diagnosis of cancer caused by such a dysfunction it is possible to.