Evaluation method of the compounds using animal and megsin / RAGE / iNOS expression disease animal model

摘要

Was without a wound (megsin / RAGE / iNOS-Tg) triple Tg and are mated to the RAGE / iNOS-Tg and megsin -Tg. This megsin / RAGE / iNOS-Tg is found that various pathological, including glomerular hypertrophy and, to early onset and diabetic renal lesions significant unconventional is observed uniformly. I have found that animals exhibiting these symptoms further, is useful as a model animal of diabetic nephropathy. That is, in the disease model animals of the present invention, it has been strongly expressed inducible nitric oxide synthase gene megsin gene, and advanced glycation end product receptor gene, and early-onset renal dysfunction associated with glomerular injury by this .