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HUMAN RGR ONCOGENE AND TRUNCATED TRANSCRIPTS THEREOF DETECTED IN T CELL MALIGNANCIES, ANTIBODIES TO THE ENCODED POLYPEPTIDES AND METHODS OF USE
HUMAN RGR ONCOGENE AND TRUNCATED TRANSCRIPTS THEREOF DETECTED IN T CELL MALIGNANCIES, ANTIBODIES TO THE ENCODED POLYPEPTIDES AND METHODS OF USE
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机译:在T细胞恶性肿瘤,编码多肽的抗体中检测到的人类RGR致癌基因及其截短的转录物及其使用方法
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摘要
Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein.
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