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Methods of Screening for Modulators of h2-Calponin Activity
Methods of Screening for Modulators of h2-Calponin Activity
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机译:筛选h2-Calponin活性调节剂的方法
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摘要
The invention provides methods for identifying modulators of mammalian, e.g., human, h2-calponin, the calponin isoform of relatively neutral pI. H2-calponin exerts an effect on the migration and proliferation of a variety of muscle (smooth muscle) and non-muscle cells and is an actin filament-associated regulatory protein influencing the structure of the actin cytoskeleton. Modulators of the activity levels of this protein are useful in preventing, ameliorating, or treating a variety of diseases, disorders or conditions characterized by aberrant cell migration and/or cell proliferation.
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