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Mapping histone modifications by DNA microarray
Mapping histone modifications by DNA microarray
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机译:通过DNA芯片定位组蛋白修饰
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摘要
Many human diseases are now realized to have epigenetic features. Post-translational modification of histones plays a major role in these epigenetic features. Chromatin immunoprecipitation assay (ChIP) is currently the method of choice for localizing histone modifications in a step-wise fashion. This technique utilizes histone modification-specific antibodies to enrich DNA (ChIP DNA), followed by the use of promoter-specific primers to localize the modification. Methods of using DNA microarrays to screen ChIPed DNA are provided herein.
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