Human chorionic gonadotropin antagonists and methods to prevent ovarian hyperstimulation

摘要

The present invention is directed to a human chorionic gonadotropin (hCG) antagonist comprising deglycosylated hCG. Methods of recombinantly producing the hCG antagonist in a glycosylation-deficient host cell are also provided. Methods of treating hCG related conditions including ovarian hyperstimulation syndrome, gestational trophoblastic disease, and hCG related tumors by administering an effective amount of the hCG antagonist are also provided herein.