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Transition state structure and inhibitors of thymidine phosphorylases
Transition state structure and inhibitors of thymidine phosphorylases
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机译:胸苷磷酸化酶的过渡态结构和抑制剂
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摘要
The transition state structure of thymidine phosphorylase is provided, along with thymidine phosphorylase inhibitors that resemble the charge and geometry of the thymidine phosphorylase transition state. Also provided are methods of inhibiting a thymidine phosphorylase, methods of treating cancer, and methods of inhibiting angiogenesis which utilize the thymidine phosphorylase transition state inhibitors.
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