Tyrosine Phosphorylation of Cdk Inhibitor Proteins of the Cip/Kip Family

摘要

The present invention is directed to tyrosine phosphorylated forms of Cip/Kip proteins including p27Kip1, fragments of these forms and antibodies thereto. The invention is further related to non-phosphorylatable forms of Cip/Kip proteins, or fragments thereof. Further embodiments are diagnostic or therapeutic uses of the disclosed compounds, in particular uses in diagnostics and therapy of hyperproliferative diseases.