Restless Legs Syndrome and Periodic Limb Movement Disorder Model Animal

摘要

The present invention provides a model animal of Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD). As a result of intraperitoneal administration to a mouse of the plasma constituents in peripheral blood collected from renal failure patients in whom RLS and PLMD were diagnosed, it was found that the mouse remarkably showed behavior pathognomonic in these diseases, and hence can be used as a model mouse of these diseases. The model animal of the present invention can be used for not only the identification of a causative substance of RLS and PLMD, but also the development and evaluation of a diagnostic method and therapy for these diseases.