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Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient
Liposomal analgesic drug compositions prepared in GMV using an ammonium sulfate gradient
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机译:使用硫酸铵梯度在GMV中制备的脂质体止痛药组合物
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摘要
Liposomal bupivacaine compositions are prepared using an ammonium sulfate gradient loading procedure, at a pH which prevents precipitation of the drug from the loading solution. Also described are liposome suspensions comprising ‘GMV’ (giant multivesicular) liposomes and methods for their preparation. The liposomal compositions are characterized by high drug-to-lipid ratios and provide long term analgesia.
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