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Use of Bcl inhibitors For The Prevention Of Fibroproliferative Reclosure Of Dilated Blood Vessels And Other Iatrogenic Fibroproliferative Disorders
Use of Bcl inhibitors For The Prevention Of Fibroproliferative Reclosure Of Dilated Blood Vessels And Other Iatrogenic Fibroproliferative Disorders
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机译:Bcl抑制剂在预防血管扩张和其他医源性纤维增生性疾病中的作用
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摘要
The present invention relates to new use of inhibitors of bcl-2/bcl-XI family of anti-apoptotic compounds for the treatment of post-angioplasty restenosis and in-stent restenosis. Small molecules of Bcl inhibitors are incorporated into a stent, typically by a fine polymeric coating over the metal, which would be placed during angioplasty of occluded blood vessels, to act on fibroproliferative in-growth. Hollow organs such as urethras, Fallopian tubes and vascular access grafts could be treated in a similar manner to prevent their closure due to fibrosis. Other iatrogenic fibrosis such as adhesions after surgery could also be blocked by this therapy.
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