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SUSTAINED-RELEASE BUPROPION AND BUPROPION/MECAMYLAMINE TABLETS
SUSTAINED-RELEASE BUPROPION AND BUPROPION/MECAMYLAMINE TABLETS
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机译:持续释放的安非他酮和安非他酮/美甲胺片
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摘要
Sustained-release bupropion hydrochloride pharmaceutical tablets and combination sustained-release bupropion hydrochloride/mecamylamine hydrochloride pharmaceutical tablets are obtained by granulating the bupropion hydrochloride with a hydroxyalkylcelluose, and blending the resulting granules within an extragranular phase composed of a particulate material that provides a sustained-release matrix, and compressing the blend into a tablet form, which then is coated, with a means to provide delayed release, such as with an enteric coating composition. The mecamylamine hydrochloride can be contained in a second granule comprising a hydroxyalkylcellulose.
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