Method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy-based pattern recognition

摘要

The present invention is directed to a method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy. More specifically, the method selectively detects reactive metabolites by eliminating false positives arising from non-reactive components including both unreactive metabolites and components of the reaction mixture.