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Human proteins responsible for NEDD8 activation and conjugation
Human proteins responsible for NEDD8 activation and conjugation
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机译:负责NEDD8激活和结合的人类蛋白质
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摘要
The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and methods for discovering molecules which are useful in detecting and/or modulating the activation and/or conjugation of NEDD8. The present invention arises from the purification and characterization of novel NEDD8 activating and conjugating enzymes.
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