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Drosophila G protein coupled receptors, nucleic acids, and methods related to the same

机译：果蝇G蛋白偶联受体，核酸及其相关方法

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摘要

The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.

机译：本发明提供了鉴定和编码这种DmGPCR的黑腹果蝇GPCR（DmGPCR）多肽和多核苷酸。另外，本发明提供表达载体，宿主细胞及其生产方法。本发明还提供了用于鉴定其他动物中的同源物以及DmGPCR激动剂/拮抗剂的方法，其可用于治疗动物中的疾病和用于防治对植物或动物有害或有害的昆虫。

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公开/公告号US7354724B2

专利类型
公开/公告日2008-04-08

原文格式PDF
申请/专利权人 DAVID E. LOWERY;VALDIN G. SMITH;TERESA M. KUBIAK;MARTHA J. LARSEN;
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申请/专利号US20030736048
发明设计人 DAVID E. LOWERY;VALDIN G. SMITH;TERESA M. KUBIAK;MARTHA J. LARSEN;
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申请日2003-12-15
分类号G01N33/53;G01N33/566;
国家 US
入库时间 2022-08-21 20:09:21

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2. Expression of fatty acid sensing G-protein coupled receptors in peripartal Holstein COWS [J] . Alea Agrawal, Abdulrahman Alharthi, Mario Vailati-Riboni, 畜牧与生物技术杂志(英文版) . 2017,第003期

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8. Free fatty acid receptors G protein‐coupled receptor 120 and G protein‐coupled receptor 40 are essential for oil‐induced gastric inhibitory polypeptide secretion [O] . Akiko Sankoda, Norio Harada, Tomoko Kato, 2019

9. 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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - 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