Deformilasa peptidyl inhibitors (PDF), useful for the treatment of tuberculosis, and Pharmaceutical compositions containing them.

摘要

Claim 1: a compound of the formula (1) or a pharmaceutically acceptable Salt, Ester or prodrug thereof wherein: N is 1 or 2; X is CH2, s or CHF; r1 is - n or - cho (o) C (o) NH (OH); R2 is alkyl, alquilcicloalquilo or alkylaryl or R2 represents a cycloalkyl Group,Where the C adjacent to the carbonyl Group is part of the cycloalkyl Ring; R3 is a Substituent of the formula (2) or (3) or tetrazolilo perimidinilo, 2 - or 4 - fenilimidazol thiocyanatoacetate; where is NH, o, S, or NR4; a, B, D and e each independently selected CHN or CR5; or a and B and D and e are CH Merge and form part of a Ring or a Heterocyclic aryl n with 5 or 6 members is hidroxialquilo alkyl; R4 or R5, heteroalquilo; heterocycle is haloalquilo, optionally substituted with an alkyl group, halogen, alkyl, amino, cyano, Nitro, aryl alkoxy,, Haloalcoxi - co2r7 - so2r8,,,NHC (R9) or - nhso2r9; or two groups together form a heterocycle containing 5 or 6 members, optionally substituted with one or more halogens and FUSED to the 6 members of the ring substituents (1); R6 is amino or alkoxy; R7 is H, alkyl, nhr10, R8 is nr10r11 or NH2. Alkyl aryl, Heterocyclic Or is aryl or heteroaryl amino; R9 and R10 and R11 each independently is an alkyl group,Alquenilo, alquinilo or aryl.