Isoindolonas potentiates metabotropic glutamate receptors, Pharmaceutical compositions that comprise and the use thereof in the manufacture of a Medicament for the treatment of Neurological and Psychiatric Disorders.

摘要

Pharmaceutical compositions containing the compounds, and Uses of the compounds in therapy of Neurological and Psychiatric Disorders.Claim 1: a compound according to Formula 1, wherein: R1 is - chr8r9; R2, R3 and R4, R6 and R7 are h; are selected independently from the group consisting of H, alkyl and Halogen C1 - 6; R5 is selected from the group formed by alkyl alkylaryl C0 - C1 - 6 6, - 6 and alq alquilheteroarilo C0 Uilheterociclilo C0 - 6; where, when Chemically possibleR5 can be replaced by one or more, and where any cyclical portion is optionally combined with a Ring of 5 to 7 members who may have one or more heteroatoms selected independently from the group consisting of N, o and S; a is selected from the group formed by alkyl Alkylaryl C0 - C1 - 6, 6, 6 alquilheteroarilo C0 - alquilheterociclilo C0, - 6, - 6 alkyl C0 (CO2) n (R10) 2Alkyl C0 - 6nr10 R10 (CO), alkyl C0 - 6 (SO2) n (R10) 2, CO (SO2) - alkyl 6nr10 R10 and a Ring of 5 to 7 members who may have one or more heteroatoms selected independently from the group consisting of N, o and S, where the Ring 5 to 7 members is optionally substituted by one or more r 10; R8 and R9 are selected independently between C1 - 6 h, alkyl, alkoxy alkyl C1 C1 - 6 - 6 -- (CH2) n - X - R10, fluoroalquilo Perfluoroalkyl C1 C1 - 6, 6 - or CN, R8 and R9 form or in combination a cycloalkyl group or a group heterociclilo C3 - 7 with the exception that R8 and R9 are not both h; n is 1, 2, 3, 4, 5 or 6; X is s or o, and R10 in each case is selected independently of Group F Composed of H, alkyl alkylaryl C0 - C1 - 6 6Alquilheteroarilo C0 - 6 and alquilheterociclilo C0 - 6 where any cyclical portion is optionally combined with a Ring of 5 to 7 members who may have one or more heteroatoms selected independently from the group consisting of N, o and S and any cyclical portion is optional Easily replaced with a Halo Substituent selected from hydroxyl, alkyl, alkoxy,Haloalquilo and haloalcoxi; or a Pharmaceutical acceptable Salt, solvate, hydrate, Optical isomer, or their combinations.