RNAi mediated inhibition of disorders related to the Histamine H1 Receptor

摘要

RNA interference is provided for inhibiting the expression of Histamine H1 Receptor mRNA, in particular for treating patients who suffer from a condition associated with hrh1 (Histamine H1 Receptor) or at risk of developing a condition associated with hrh1 as conjunctivitis Ocular inflammation, dermatitis, allergic rhinitis, Asthma, or allergies.Claim 1: the use of interfering RNA for the manufacture of a drug that reduces the mrna expression of Histamine H1 Receptor in a subject, comprising: Administering to the subject a composition comprising an effective amount of RNA interference has a length of 19 49 Nucleotides and a vehicle acceptable for pharmaceutical use.RNA interfering RNA comprising a selected from the group consisting of: a region of at least 13 contiguous nucleotides that have at least 90% of Sequence complementarity,Or at least 90% Sequence identity with the Penultimate 13 nucleotides to the 3 'end of the mRNA corresponding to any of the SEC and 2 sec id id HL HL HL 13 sec id 50; a region of at least 14 nucleotides contiguous with at least 85% of Sequence complementarity, or P Or at least 85% Sequence identity.With the Penultimate 14 nucleotides to the 3 'end of an mRNA for any of the SEC and 2 sec id id HL HL HL 13 sec id 50; and a region of at least 15, 16, 17 or 18 contiguous nucleotides has at least 80% of Sequence complementarity, or at least 80% Identity With the Penultimate sequence, 15, 16, 17 or 18 nucleotides, respectively,The 3 'end of an mRNA for any of the SEC and 2 sec id id HL HL HL 13 sec id 50; where the mrna expression of Histamine H1 Receptor attenuates this way.