Diazeniodiolatos Derivatives, Preparation method and Pharmaceutical compositions containing them and uses in cardiovascular pathologies.

摘要

Claim 1: compounds of formula (1): in which R1 represents a group alcanoilo C1 - 6 linear or branched alkyl; R2 represents a linear or branched C1 - 6 replaced with a group G, and R1 and R2 are along with the nitrogen atom of a group which contains imidazolilo or bencimidazolilo,While these groups substituted with a group G and optionally substituted with one or two additional groups selected from C1 - 6 linear or branched alkyl, alkoxy C1 - 6 linear or branched, and Halogen ATOMS, and G is a Group (CH2) - N - (CH2) M - (P - cr4r5) - (CH2) or R3 where n is 0: 1, 2, or 3 m, 0,1, 2 or 3, p is 0 OR 1, or 0,1 or 2; R4 and R5, identical or different,Represent each a hydrogen Atom or a linear or branched alkyl C1 - 6, with one of the - CH2 - groups or Chain - of - cr4r5 G can also be replaced by a phenylene Group, PHC (PHC) - or - (OR) - or (in which pH is understood phenyl), represents a group of formulas (2 R6) which represents a hydrogen Atom or an alkyl group C1 - 6 linear or branched.And R3 represents a group of formulas (3) R7, R8 and R9, identical or different, represent each a hydrogen Atom, an alkyl group or C1 - 6 or linear or branched, R7 and R8 together form a Chain alquileno C1 - 6 linear or branched, its enantiomers and Diastereomers and its Salt It is in addition to a pharmaceutically acceptable acid or a base.