uses of 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido 2,3-d pyrimidine derivatives and related compounds for the treatment of cancer, its pharmaceutical compositions, commercial packaging and its kit

摘要

USES OF 5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO ¢ 2,3-D! PYRIMIDINE AND RELATED COMPOUNDS FOR CANCER TREATMENT, PHARMACEUTICAL COMPOSITIONS, COMMERCIAL PACKAGING AND THEIR KIT. The present invention relates to a pyrimidine compound represented by the formula II. hereinafter each symbol is defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, in particular an antitumor agent, which contains such a compound. The compound of the present invention has superior undesirable cell proliferation suppressive action, in particular antitumor action, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, antireumatoid agent and the like. Furthermore, by combined use with another antitumor agent such as an alkylating agent, a metabolism antagonist and the like, it may be a more effective antitumor agent.