compound and a pharmaceutically acceptable salt or prodrug or solvate thereof, composition, methods of inhibiting checkpoint kinase 1 in a cell, of sensitizing cells in an individual undergoing chemotherapeutic or radiotherapeutic treatment for a medical condition and of inhibiting aberrant cell proliferation, use of a compound, and article of manufacture for pharmaceutical use in human

摘要

COMPOUND AND A PHARMACEUTICALLY ACCEPTABLE SALT OR PRODUCT OR SOLVATE OF THE SAME, COMPOSITION, METHODS OF INHIBITING A CELL POINT KINASE 1, OF SENSITIZING CELLS IN A MATERIAL AND A PASSATIC TRADIUM BY A PASTERIC DIAGNOSIS OF INHIBITING OPEN CELL PROLIFERATION, USE OF A COMPOUND, AND MANUFACTURING ARTICLE FOR PHARMACEUTICAL USE IN HUMAN Substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or DNA replication damage are disclosed. Methods of manufacturing the compounds and their use as therapeutic agents, for example in the treatment of cancer and other diseases characterized by defects in DNA replication, chromosome segregation or cell division are also disclosed.