methods of determining the efficacy of therapy in the treatment of amyloidosis and of identifying patients as prodromal for disease associated with amyloid deposition and its compounds

摘要

Methods of Determining the Effectiveness of Therapy in the Treatment of Amyloidosis and Identifying the Patient as a Prodromal for Disease Associated with Amyloid Deposition and Compounds thereof The present method for determining the efficacy of therapy in the treatment of amyloidosis involves administering to the patient in need a compound of the amyloidosis. formula (I) or Formula (II) or structures 1-45 and capture patient images. After capturing said images, at least one anti-amyloid agent is administered to said patient. Then, an effective amount of a compound of formula (I) or Formula (II) or structures 1-45 is administered to the patient and the patient is again captured. Finally, baseline levels of patient amyloid deposition prior to anti-amyloid agent treatment are compared with patient amyloid deposition levels following anti-amyloid agent treatment.