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use of aspartate equivalents and at least one of vitamin b12 and biotin, and enteral nutritional composition

机译:使用天冬氨酸当量和维生素b12和生物素中的至少一种以及肠内营养成分

摘要

USE OF ATTACHMENT EQUIVALENTS AND AT LEAST ONE OF VITAMIN B12 AND BIOTINE AND ENTERAL NUTRITIONAL COMPOSITION It has been found that high amounts of aspartate equivalents in combination with vitamin B12 and / or biotin, especially in the relative absence of glutamate equivalents, improve metabolism of ketone and / or lactate bodies in a mammalian body, especially under disease or traumatic conditions. As a result, ketone and lactate body level levels may be decreased and non-physiologically high acidity normalized. Thus, it is an object of the invention to provide an enteral or pharmaceutical nutritional composition for the treatment and / or prevention of disturbed ketone and lactate metabolism, i.e., high concentrations of ketone bodies, lactate and / or other organic acids and / or homeostasis. at insufficient pH, especially high concentrations of ketone and / or lactate bodies, in a mammalian blood, wherein the composition comprises high amounts of aspartate equivalents in combination with vitamin B 12 and / or biotin, preferably in the relative absence of equivalents. of glutamate.
机译:至少当使用维生素B12和生物素以及肠内营养组合物时,已经发现当与维生素B12和/或生物素联合使用时,尤其是在相对缺乏谷氨酸盐的情况下,高天冬氨酸当量的大量使用可改善酮的代谢和/或哺乳动物体内的乳酸体,尤其是在疾病或外伤条件下。结果,酮和乳酸体水平可以降低并且非生理性高酸度可以归一化。因此,本发明的目的是提供一种用于治疗和/或预防酮和乳酸代谢紊乱的肠或药物营养组合物,即高浓度的酮体,乳酸和/或其他有机酸和/或体内平衡。 。在哺乳动物血液中在pH不足,尤其是高浓度的酮和/或乳酸体的条件下,其中所述组合物包含与维生素B 12和/或生物素组合的高含量的天冬氨酸当量,优选在相对当量的情况下。谷氨酸。

著录项

  • 公开/公告号BRPI0513551A

    专利类型

  • 公开/公告日2008-05-06

    原文格式PDF

  • 申请/专利权人 N.V. NUTRICIA;

    申请/专利号BR2005PI13551

  • 发明设计人 ROBERT JOHAN JOSEPH HAGEMAN;

    申请日2005-07-18

  • 分类号A61K38/02;A23L13/40;A23L13/60;A23L23/10;A23L33;A61K31/4188;A61K31/714;A61K38/16;A61P3;

  • 国家 BR

  • 入库时间 2022-08-21 20:08:46

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