Metal complexes with compounds indu00f3licos, oxindu00f3licos and its derivatives imu00ecnicos, processes for their production, their pharmacological activities such as anti tumour agents, use of these complexes and derivatives in the formulation of medicines for the treatment of tumors and medicines for this Treatment of tumors

摘要

Metal complexes with compounds indu00f3licos, oxindu00f3licos and its derivatives imu00ednicos, processes for their production, their pharmacological activities such as anti tumour agents, use of these complexes and derivatives in the formulation of medicines for the treatment of tumors and medicines for this Treatment of tumors.The present invention relates to metal complexes with compounds indu00f3licos, oxindu00f3licos and its derivatives imu00ednicos to respective processes of production and characterization. Also refers to the biological activity of these complexes and derivatives, especially the pharmacological activities res Only the cells of human tumour and its use in the formulation of medicines.The invention also relates to products containing such complexes and derivatives in treatment of tumors.More specifically, it is the preparation, identification and verification of the biological activity of the substances synthesized, from indu00f3licos oxindu00f3licos compounds, such as isatina, and different amines, subsequently metaladas with copper or other metals as essential. Iron, zinc, vanadium, cobalt, nickel, magnesium and manganese.In cultures of human tumour cells (e.g. promocu00edticas U937 and neuroblastomas HS SY5Y). Indu00f3is and its derivatives are natural products found in plants, in addition to being one of the products of the metabolism of adrenaline in human beings. By itself, some indu00f3is, as isatina, have various pharmacological activities.The products (1), (3) and (5) corresponding to copper complexes with Schiff bases derived from isatina showed antiproliferative and apoptotic activity in cultures of cells used, acting at different stages of the cell cycle, at a concentration of 10 to 50 variable 109 mol / L, q The EU has potential application as an efficient anti tumour agents.