Derivatives of 2 - substituted imidazole Compounds, Preparation Method, Pharmaceutical composition comprising these Compounds, and their use to treat Depression, anxiety, bipolar disorder,Attention deficit hyperactivity, thing

摘要

The present invention relates to compounds of formula I wherein R1 is selected from the group consisting of hydrogen and lower alkyl; each R2 is independently selected from the group consisting of hydrogen and lower alkyl; each R3 is independently selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, phenyloxy, benzyloxy, halogen and lower alkyl substituted by halogen; X is selected from the group consisting of CH2, CH and O; Y is selected from the group consisting of CH2, CH and a bond with the proviso that, when X is O, Y may not be a bond; Z is selected from the group consisting of CH2 and CH; m is 0, 1 or 2; and n is 0, 1 or 2; and to pharmaceutically-acceptable acid addition salts of such compounds. The invention relates also to processes for preparing such compounds, compositions comprising such a compound or a pharmaceutically-acceptable acid addition salt thereof, and a method of treating a disease or disorder in a patient comprising administering such a compound, or pharmaceutically-acceptable acid addition salt thereof, to a patient in need of such treatment.