Method to avoid or reduce vasoconstriction following Administration of vasoactive Oxygen Carrier,Comprising nitric oxide Gas and another ACTIVE AGENT; Pharmaceutical composition comprising an inhibitor of fosfodiesteras

摘要

A gas delivery device is disclosed, the gas delivery device comprising a lumen configured to route a gas into the respiratory system of a mammal, a first meter configured to measure the concentration of nitric oxide gas present in the lumen, a second meter configured to measure the rate of gas flow in the lumen, and a dosimeter that integrates the concentration of nitric oxide measured in the lumen with the rate of gas flow measured in the lumen to determine the amount of nitric oxide delivered by the device to the respiratory system of the mammal. The device may further comprise a vessel with pressurized gas comprising with at least 1 ppm nitric oxide, the vessel having a mechanism for controllably releasing the pressurized gas into the lumen or into a chamber in communication with the lumen. The release of the pressurized gas may be triggered by negative inspiratory pressure of the mammal and limited to the inspiratory cycle of respiration.