Azacicloalcanos derived Compounds, inhibitors of Stearoyl coenzyme a delta-9 desaturase; Pharmaceutical Composition and use for the treatment of diseases such as type 2 diabetes,Insulin resistance, Lipid disorders, Obesity

摘要

Azacycloalkane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.