Compounds 4 - aryl - 3 - pyridazine hydrochloride,Antagonists of dopamine receptor 2 Rapid Dissociation; Pharmaceutical composition comprising these Compounds, and their use as antipsychotics for the Treatment or prevention of esquizofrEnia,

摘要

The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.