首页> 外国专利> Crystalline form of Salt - endo - (3 - 2 - 2 - ((S) - cyclohexylmethyl 2,3-dihydroxy - Propionyl) amino ethyl - 8aza Bicyclo 3.2.Oct 1 - 3 - il) benzamide; Process for preparing the Salt, Pharmaceutical composition comprising such a Sa and their use in disfu

Crystalline form of Salt - endo - (3 - 2 - 2 - ((S) - cyclohexylmethyl 2,3-dihydroxy - Propionyl) amino ethyl - 8aza Bicyclo 3.2.Oct 1 - 3 - il) benzamide; Process for preparing the Salt, Pharmaceutical composition comprising such a Sa and their use in disfu

机译:盐的结晶形式-内-(3- [2- [2-((S)-环己基甲基2,3-二羟基-丙酰基)氨基]乙基]乙基] -8aza双环[3.2.Oct 1]-3-il)苯甲酰胺;制备盐的方法,包含这种盐的药物组合物;及其在disfu中的使用

摘要

The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamideor a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
机译:本发明提供了3-内-(8- {2- [环己基甲基-((S)-2,3-二羟基-丙酰基)氨基]乙基] -8-氮杂-双环[3.2.1] oct的结晶硫酸盐-3-基)苯甲酰胺或其溶剂化物。本发明还提供了包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与μ阿片受体活性有关的疾病的方法,以及用于制备这种结晶盐形式的方法。

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