Reconstituable, selective COX-2 inhibitory pharmaceutical composition, process for its preparation, injectable solution and pharmaceutical article

摘要

In the present invention, there is disclosed a reconstituable, selective COX-2 inhibitory pharmaceutical composition comprising, in powder form: (a) at least one water-soluble therapeutic agent selected from selective COX-2 inhibitory drugs and prodrugs and salts thereof, in a therapeutically effective total amount constituting about 30 to about 90 percent by weight, (b) a parenterally acceptable buffering agent in an amount of about 5 to about 60 percent by weight, and (c) other parenterally acceptable excipient ingredients in a total amount of zero to about 10 percent by weight, of the composition; said composition being reconstituable in a parenterally acceptable solvent liquid to form an injectable solution. There is also disclosed a process for preparing the above-indicated pharmaceutical composition, an injectable solution reconstituted therefrom as well as an article of manufacture comprising a sealed vial having contained therewithin a unit dosage amount of the above-described pharmaceutical composition in a sterile condition.