8-METHOXY-9H-ISOTHIAOSOLO 5,4-b QUINOLIN-3,4-DIONA AND RELATED COMPOUNDS AS ANTI-INFECTIOUS FUNDS

摘要

The invention relates to a compound and salts of formula (I) and (II) described herein, which include compounds of formula (A) and formula (B), such compounds possess useful antimicrobial activity. The variable substituents R, R, R, R, R and R shown in formulas A and B are defined herein. Some compounds of formula (I) and formula (II) described herein are potent and / or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also relates to antimicrobial compositions comprising pharmaceutical compositions containing one or more compounds of formula (I) or formula (II) and one or more carriers, excipients or diluents. Such compositions may contain a compound of formula (I) or formula (II) as the sole active substance or a combination of a compound of formula I or formula II and one or more other active substances. The invention relates to methods for treating microbial infections in animals.